Table 2 Profiling compound E5 on kinase inhibition.

From: Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells

Kinase

IC50 (µM)a

Kinase

IC50 (µM)a

PDGFRα

0.40

FGFR1

>25

PDGFRβ

0.93

FGFR2

>25

c-KIT

0.51

B-raf

>25

CSF1R

1.12

Raf-1

>25

FLT3

>25

EGFR

>25

ABL1

9.35

BLK

>25

ABL2

4.36

LCK

>25

  1. aIC50: 50% inhibitory concentration (averages of two separate experiments).
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