Table 1 Clinicopathological characteristics and overall survival rate in 378 patients with distal bile duct cancer.

Parameters	N = 378	OS rate (%)			MST (95% CI)
Parameters	N = 378	1-year	3-year	5-year	Month	p value^*
Age
<65 y	196	84.2	56.6	45.4	30	0.101
≥65 y	182	80.8	47.3	41.2	22
Sex
Male	253	81.8	51	41.9	30	0.698
Female	125	84	54.4	46.4	22
Gross type
Papillary	25	88	68	56	39	0.002 ^†
Nodular	56	87.5	62.5	55.4	33
Infiltrative	297	81.1	48.8	40.1	25
Histological grade
Well	81	91.4	71.6	56.8	50	<0.001 ^‡
Moderate	229	83.8	51.1	43.2	27
Poor	68	67.6	32.4	27.9	16
AJCC stage
I	94	87.2	66	54.3	47	0.169^§
IIA	136	86	61	51.5	32
IIB	120	75.8	35.8	30	20	0.426^§
IIIA	28	78.6	32.1	25	19
T criteria
1	142	86.6	61.3	52.1	43	0.164^¶
2	186	81.2	47.8	39.8	24
3	50	76	42	32	19
N criteria
0	196	86.7	64.3	53.1	39	0.138^‖
1	154	77.9	40.3	34.4	22
2	28	78.6	32.1	25	19
Size (cm)
<2.5	184	84.2	56	47.3	33	0.111
≥2.5	194	80.9	48.5	39.7	24
Pancreas invasion
Absence	181	84	59.1	49.7	35	0.021
Presence	197	81.2	45.7	37.6	22
Duodenal invasion
Absence	322	84.8	55.3	46.6	30	<0.001
Presence	56	69.6	33.9	25	19
Gallbladder invasion
Absence	375	82.4	52	43.7	27	0.43
Presence	3	100	66.7	—	47
Lymphatic invasion
Not identified	225	86.7	60	50.2	34	0.005
Present	153	76.5	40.5	33.3	21
Perineural invasion
Not identified	119	88.2	66.4	60.5	42	<0.001
Present	259	79.9	45.6	35.5	24
Margin involvement
Not involved	287	84.7	55.1	45.3	31	0.015
Involved	91	75.8	42.9	37.4	21

AJCC, 8^th edition of American Joint Committee on Cancer; OS, overall survival; MST, median survival time.
^*Log Rank test.
^†papillary and nodular versus infiltrative type.
^‡Well and moderately versus poorly differentiated.
^§I versus IIA IIB versus IIIA.
^¶T2 versus T3.
^‖N1 versus N2.
P-values < 0.05 are in bold.

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