Table 2 Clinicopathological difference in patients with and without organ involvement in 378 patients with distal bile duct cancer.
Parameters | N = 378 | Adjacent organ invasion | p-value (χ2 test) | |
|---|---|---|---|---|
no organ invasion (n = 174), % | organ invasion (n = 204), % | |||
Age | ||||
   <65 y | 196 | 83 (47.7) | 113 (55.4) | 0.136 |
   ≥65 y | 182 | 91 (52.3) | 91 (44.6) |  |
Sex | ||||
   Male | 253 | 125 (71.8) | 128 (62.7) | 0.061 |
   Female | 125 | 49 (28.2) | 76 (37.3) |  |
Gross type | ||||
   Papillary | 25 | 18 (10.3) | 7 (3.4) | <0.001 * |
   Nodular | 56 | 35 (20.1) | 21 (10.3) |  |
   Infiltrative | 297 | 121 (69.5) | 176 (86.3) |  |
Histological grade | ||||
   Well | 81 | 48 (27.6) | 33 (16.2) | 0.003 * |
   Moderate | 229 | 102 (58.6) | 127 (62.3) |  |
   Poor | 68 | 24 (13.8) | 44 (21.6) |  |
N criteria | ||||
   0 | 196 | 96 (55.2) | 100 (49) | 0.08* |
   1 | 154 | 70 (40.2) | 84 (41.2) |  |
   2 | 28 | 8 (4.6) | 20 (9.8) |  |
Size (cm) | ||||
   <2.5 | 184 | 92 (52.9) | 92 (45.1) | 0.132 |
   ≥2.5 | 194 | 82 (47.1) | 112 (54.9) |  |
Lymphatic invasion | ||||
   Not identified | 225 | 118 (67.8) | 107 (52.5) | 0.002 |
   Present | 153 | 56 (32.2) | 97 (47.5) |  |
Perineural invasion | ||||
   Not identified | 119 | 66 (37.9) | 53 (26) | 0.013 |
   Present | 259 | 108 (62.1) | 151 (74) |  |
Margin involvement | ||||
   Not involved | 287 | 109 (62.6) | 178 (87.3) | <0.001 |
   Involved | 91 | 65 (37.4) | 26 (12.7) |  |
