Table 1 Characteristics of the longitudinal follow-up studies included in the analysis.

From: Natural Course of Clinically Isolated Syndrome: A Longitudinal Analysis Using a Markov Model

Author

Year

Diagnostic criteria

Initial status

Number of patients (n)

Female/Male

Age of onset

Follow-up (years)

I. O’ Rordan3

1998

Definite

CIS

81

53/28

32.3

10

L. K. Fisniku4

2008

CIS or possible

110

73/37

32.0

20

M. Eriksson15

2003

MS Poser

308

186/122

NA

25

P. A. Brex21

2002

criteria

71

49/22

32.0

14

S. J. Pettock34

2004

Poser

RRMS

48

NA

NA

10

H. Tremlett35

2009

criteria

2454

1457/997

NA

25

H. Tedeholm5

2015

 

212

137/75

NA

50

J. Kuhle30

2015

Poser

SPMS

176

NA

41

10

N. G. Torkildsen31

2008

criteria

878

545/333

32.9

50

  1. Initial status: the status of each patient cohort at the onset of longitudinal follow-up. CIS: clinically isolated syndrome; RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis. NA: not available.