Table 3 Estimated regression coefficients for COD yield.

From: Response Surface Methodology-Genetic Algorithm Based Medium Optimization, Purification, and Characterization of Cholesterol Oxidase from Streptomyces rimosus

Effect

Coefficients

SE

Wald Stat.

p-value

Intercept

−0.1801

0.26183

33.64008

<0.0001

Var1

2.8746

0.50285

49.49338

<0.0001

Var12

0.4879

0.24010

11.39588

0.000736

Var2

0.46960

0.43527

4.99551

0.025413

Var22

−0.112

0.17871

0.48697

0.485280

Var3

1.35105

0.21073

39.91996

<0.0001

Var32

0.01418

0.04532

1.43576

0.230827

Var4

−32.5579

8.95763

0.00056

0.981069

Var42

−302.301

74.69575

7.13023

0.007579

Var1*Var2

−0.01250

0.53368

1.29396

0.255319

Var1*Var3

−1.95938

0.18269

75.60701

<0.0001

Var2*Var3

−1.1750

0.19853

19.22840

0.000012

Var1*Var4

48.37499

10.43085

1.10629

0.292891

Var2*Var4

65.4999

11.06510

5.01864

0.025076

Var3*Var4

16.0625

3.96512

0.33786

0.561066

  1. Note: Var1 = yeast extract, Var2 = dextrose, Var3 = starch, Var4 = ammonium carbonate. SE = standard error. Wald Stat = Wald statistics. The p-values less than 0.05 are significant.
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