Table 4 Association between LS-BMD and FN-BMD and genotypes of common and LFV WNT16, DKK1 and SOST variants.

From: Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density

SNP

Position

Type

P value LS-BMD

P value FN-BMD

 

A

R

D

A

R

D

WNT16

    

rs55710688

p.Met1?

g.120965467_120965470dupCCCA

Fs 5′UP

0.0037

0.0283

0.0116

0.0479

0.1026

0.0991

rs2908004

p.G72R/p.G82R

M

0.0263

0.2152

0.0192

0.0510

0.0894

0.1254

rs142005327

c.346 + 103_104dupCT

c.316 + 103_104dupCT

I

0.0037

0.008

0.0235

0.0191

0.1454

0.0285

rs2707466

p.T253I/p.T263I

M

0.0182

0.1252

0.0188

0.0167

0.0504

0.0439

rs3801387#

c.603 + 2747 A > G

c.633 + 2747 A > G

I

0.0081

0.0060

0.0609

0.0416

0.1032

0.0862

DKK1

rs1569198

c.548–43 A > G

I

0.3626

0.726

0.2635

0.0095

0.0362

0.0307

rs74711339

c.*82 A > G

3′UTR

0.7960

0.0752

0.9498

0.0682

0.3901

0.0801

rs1373004#

10:g.54427825 T > G

I

0.0543

0.1582

0.0867

0.585

0.4641

0.4006

SOST

rs1237278

g.41838229 C > T

5′UP

0.9395

0.7643

0.9395

0.0955

0.4533

0.0718

rs2023794

g.41837660 T > C

5′UP

0.5142

0.4199

0.6018

0.6703

0.6838

0.5965

rs17882143

p.Val10Ile

M

0.0669

0.1204

0.0352

0.9888

  

rs17883310

c.*320 C > T

3′UTR

0.2236

0.6254

0.3454

0.6152

0.7935

0.6319

rs4792909#

g.41798824 G > T

5′UP

0.2158

0.1895

0.4355

0.1757

0.1537

0.3874

  1. Fs: Frameshift; I: Intronic; M: Missense; 5′UP: 5′upstream; 3′D: 3′ downstream. Values in italics indicate nominal significance. Values in bold indicate Bonferroni’s significance. #SNP previously genotyped in BARCOS (Estrada et al.)6. A: Additive model; R: Recessive model; D: Dominant model.
  2. Reference allele for the dominant and recessive models was the minor allele.
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