Table 4 Cox proportional hazard models exploring the association of iron quartiles with 90-day mortality.
From: High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis
Factors | Univariate model | Multivariate model | ||
|---|---|---|---|---|
Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
Gender (male) | 1.217 (1.034–1.433) | 0.018 | 1.067 (0.903–1.260) | 0.445 |
Age | ||||
   16–30 | Reference | — | Reference | — |
   31–59 | 1.762 (0.861–3.606) | 0.121 | 1.383 (0.673–2.842) | 0.378 |
   ≥60 | 3.555 (1.767–7.151) | <0.001 | 2.677 (1.316–5.445) | 0.007 |
Diabetes | 0.989 (0.830–1.179) | 0.902 | — | — |
Hypertension | 0.828 (0.700–0.982) | 0.030 | 0.872 (0.733–1.039) | 0.125 |
Malignancy | 1.879 (1.578–2.238) | <0.001 | 1.770 (1.480–2.117) | <0.001 |
Congestive heart failure | 1.554 (1.320–1.829) | <0.001 | 1.433 (1.205–1.704) | <0.001 |
SOFA score | 1.138 (1.114–1.162) | <0.001 | 1.114 (1.088–1.140) | <0.001 |
Adequate antimicrobial therapy | 0.942 (0.789–1.124) | 0.505 | — | — |
Tight glucose control | 0.691 (0.488–0.976) | 0.036 | 0.770 (0.543–1.090) | 0.141 |
Hydrocortisone replacement | 1.547 (1.225–1.954) | <0.001 | 1.009 (0.790–1.287) | 0.946 |
Lactate | 1.092 (1.058–1.128) | <0.001 | 1.076 (1.039–1.115) | <0.001 |
Hemoglobin | 0.926 (0.890–0.963) | <0.001 | 0.936 (0.899–0.975) | 0.001 |
Creatinine | 1.022 (0.990–1.055) | 0.182 | — | — |
WBC | 1.002 (0.994–1.011) | 0.611 | — | — |
Transferrin | 0.996 (0.995–0.998) | <0.001 | 0.997 (0.996–0.999) | <0.001 |
Ferritin | 1.000 (1.000–1.000) | <0.001 | 1.000 (0.999–1.000) | 0.393 |
Iron quartiles | ||||
   First | Reference | — | Reference | — |
   Second | 1.148 (0.901–1.463) | 0.265 | 1.149 (0.900–1.468) | 0.265 |
   Third | 1.307 (1.033–1.653) | 0.025 | 1.309 (1.031–1.660) | 0.027 |
   Fourth | 1.506 (1.196–1.896) | <0.001 | 1.506 (1.190–1.908) | <0.001 |
