Table 1 Volatile metabolites detected in the fecal microbiota volatolome as significantly altered by the pollutants. DeltaM: deltamethrin.

From: Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

Volatile Metabolite

m/za

LRIb

IDc

p-valued

Ratio (Pollutant / Vehicle)

DeltaM

PhIP

TCDD

PAHs

DeltaM

PhIP

TCDD

PAHs

Sulfur compounds

Carbon disulfide

76

<600

a,b

  

7.4E-04

   

3.80

 

Dimethyl disulfide

94

748

a,b

2.3E-03

 

1.8E-03

 

1.69

 

2.14

 

Dimethyl trisulfide

126

983

a,b

2.5E-03

 

5.5E-05

 

1.78

 

2.39

 

4- or 5-methyl-2-acetylthiazole

126

1116

a,b

  

2.3E-03

   

1.51

 

Dimethyl tetrasulfide

79

1243

a,b

1.0E-03

 

9.6E-04

 

3.68

 

6.21

 

Thioesters

           

S-methyl 3-methylbutanethioate

85

945

a

  

2.3E-03

   

1.46

 

Phenols

4-methylphenol

105

1076

a,b

   

3.0E-04

   

1.30

Esters

Propylphenylacetate

91

1345

a,b

   

3.0E-03

   

2.86

Ketones

2,2,4,4-tetramethyl-3-pentanone

85

939

a,b

4.0E-06

0.0E + 00

2.0E-06

 

0.52

0.56

0.53

 

Methylacetophenone

119

1198

a,b

   

2.2E-04

   

1.61

Hydrocarbons

m- or p-xylene

91

875

a,b

4.0E-04

2.1E-04

  

0.38

0.38

  

Unknown

Unknown

57

<600

    

8.3E-04

   

0.37

Totale

       

5

2

7

4

  1. aMass fragment used for peak area determination.
  2. bLinear retention index on a RTX-5MS capillary column.
  3. cTentative identification based on (a) mass spectrum, (b) linear retention index from the literature.
  4. dP-values corrected for multiple testing.
  5. eTotal number of volatiles significantly altered by the pollutants.
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