Figure 1

Wdfy3 protein domains, protein network and pathways. (A) Schematic representation of human Wdfy3 protein domains and repeats constructed according to InterPro database information. The positions of the pathogenic mutations reported in subjects are indicated on the diagram as well as the homologous positions of the mouse alleles. (B) Network of proteins associated with Wdfy3. Network nodes represent proteins whereas the edges represent protein-protein interactions (physical, functional). Analysis was performed with STRING⁷⁵, utilizing the following settings: minimum interaction score of 0.4; first shell of <10 interactors and the second shell with <5. The active interaction sources were text mining, experimental, databases, co-expression, neighborhood, gene fusion and co-occurrence. The line thickness indicates the strength of the data supporting the network edges. (C) Gene ontology of biological pathways associated with Wdfy3 from STRING analysis. Pathways were filtered by a false discovery rate <0.05. From these (31 pathways), only the top 5 are shown. In bold and italics, pathways associated with autophagy and mitophagy.