Table 1 IC50 values and PfCRT and PfMDR1 mutations of P. falciparum parasites used in this study.

From: Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites

Strain

CQ

CQ + VP

VP

PfCRT

PfMDR1

(nM)

(nM)

(µM)

76

86

184

1034

1042

1246

3D7

24 ± 6

17 ± 1

38 ± 6

K

N

Y

S

N

D

HB3

14 ± 1

19 ± 2

50 ± 2

K

N

F

S

D

D

Dd2

169 ± 4

53 ± 7

33 ± 4

T

Y/Fa

Y

S

N

D

FCB

166 ± 9

41 ± 7

34 ± 7

T

Y

Y

S

N

D

  1. Values obtained from three independent experiments ± SEM.
  2. CQ, chloroquine; VP, verapamil.
  3. aDescribed in26,27.
Back to article page