Figure 9 | Scientific Reports

Figure 9

From: In vivo delineation of glioblastoma by targeting tumor-associated macrophages with near-infrared fluorescent silica coated iron oxide nanoparticles in orthotopic xenografts for surgical guidance

Figure 9

Characterization of targeting and distribution of NF-SIONs in the brain tumor region (A–D) and non-tumor region (E–H) by immunofluorescence staining, 8 hr after injection. The shown sections were stained with monoclonal antibodies (mAbs; green) against Ki-67 (A and E, proliferating cells), CD31 (B and F, endothelial cells/macrophages), F4/80 (C and G, macrophages), and CD11b (D and H, monocytes/macrophages). Blue and red signals show the location of cell nucleus and NF-SIONs, each. White circles indicate co-localization of TAMs and NF-SIONs, and the hole seen in the tumor region was due to the injection process of tumor cells. Scale bar: 50 μm (×40).

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