Figure 5 | Scientific Reports

Figure 5

From: L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy

Figure 5

Voluntary running wheel activity in 6-week old TgACTA1D286G mice receiving a 2% L-tyrosine supplemented diet from preconception compared to TgACTA1D286G and WT C57BL/6 J mice fed an untreated diet. Parameters of voluntary running wheel performance measured included (A) maximum speed (m/min), (B) distance travelled (km/d), (C) average speed (m/min), and (D) duration spent running (min/d). Untreated TgACTA1D286G mice (10 males, 12 females), L-tyrosine treated TgACTA1D286G mice (14 males, 17 females), untreated WT C57BL/6 J mice (15 males, 10 females). Each data point represents an individual mouse average calculated over days 4, 5, and 6 of voluntary wheel access ± s.d. *p < 0.05, **p < 0.01, ***p < 0.001.

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