Figure 2
From: Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models
Results from enrichment and network analysis comparing expression profiles of LSECs in 3DHLK models to 3DHL models. (a) Network computed by the MCMC-BPN algorithm. Each node is an enriched gene set reported by GSEA. Each link connects two gene sets. Red nodes are up-regulated and blue nodes are down-regulated in LSEC from the 3DHLK model. (b) Protein-protein and regulatory interactions up-stream of Ppara in the PPAR Signaling Pathway. Proteins highlighted in pink were up-regulated in LSECs in the 3DHLK model. (c) Protein interactions underlying the link between the PPAR Signaling Pathway (purple nodes) and the Terpenoid Backbone Biosynthesis Pathway (green nodes) in the BPN displayed in (a). Nodes with a saturated color are in the leading edge. Note that Hmgcs2 is annotated to both pathways. (d) Reactions involved in cholesterol biosynthesis. Pink proteins belong to the leading edge of either the Terpenoid Backbone Biosynthesis or the Steroid Biosynthesis pathway.
