Figure 4
From: Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei
Alignment of the C-termini of SEC13 from rodent (P. berghei) and human (P. falciparum) infecting malaria species, and polyproline exchange strategy. (A) ClustalW aligenment of the SEC13 C-terminal polyproline domain from P. berghei (top sequence) and P. falciparum (bottom sequence) starting with the highly conserved, sixth WD-domain of both proteins. Red underlined are six documented phosphorylation sites in the P. falciparum protein. (B) Schematic summary of viable and non-viable P. berghei mutants. (C) Live imaging of SEC13PF3D7PP shows unaltered protein localisation. Scale bar: 5 µm.
