Figure 1 | Scientific Reports

Figure 1

From: ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes

Figure 1

Intratumoral TLS formation in breast cancer patients share features of secondary lymphoid organs. Serial sections of tumor tissue showing the acquisition of features of secondary lymphoid organs with segregation of T cells and B cells into separate areas. (a) HE staining showing representative TLS formation with GC in breast tumor tissue. (b) CD3+, (c) CD4+, and (d) CD8+ T cells with development of (e) PNAd+ HEVs in the periphery of the T cell zone. (f) CD20+ B cells intermingled with a network of (g) CD21+ FDC that supports a functional germinal center response with (h) Bcl6 positive B cells. Solid black line: T cell area; dotted black line: B cell area. Original magnification, X100.

Back to article page