Table 3 Distribution of four polymorphisms and the association with NIHL.
From: DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
Gene | Genetic models | Genotypes | Cases | Controls | P a | Adjusted OR | ||
|---|---|---|---|---|---|---|---|---|
n = 527 | % | n = 527 | % | (95% CI)b | ||||
DNMT3A | rs7578575 | |||||||
Codominant | AA | 36 | 6.8 | 36 | 6.8 | 0.426 | 1.00 (Ref.) | |
AT | 203 | 38.5 | 183 | 34.7 | 1.11(0.67–1.84) | |||
TT | 288 | 54.6 | 308 | 58.4 | 0.94(0.57–1.53) | |||
Dominant | TT | 288 | 54.6 | 308 | 58.4 | 0.214 | 1.00 (Ref.) | |
AA/AT | 239 | 45.4 | 219 | 41.6 | 1.17(0.91–1.49) | |||
Recessive | AT/TT | 491 | 93.2 | 491 | 93.2 | 1.000 | 1.00 (Ref.) | |
AA | 36 | 6.8 | 36 | 6.8 | 1.00 (0.62–1.62) | |||
Alleles | T | 779 | 73.9 | 799 | 75.8 | 0.315 | 1.00 (Ref.) | |
A | 275 | 26.1 | 255 | 24.2 | 1.11 (0.91–1.35) | |||
DNMT3A | rs749131 | |||||||
Codominant | TT | 206 | 39.1 | 226 | 42.9 | 0.009 | 1.00 (Ref.) | |
GT | 247 | 46.9 | 258 | 49.0 | 1.05 (0.81–1.35) | |||
GG | 74 | 14.0 | 43 | 8.2 | 1.87 (1.24–2.87) | |||
Dominant | TT | 206 | 39.1 | 226 | 42.9 | 0.210 | 1.00 (Ref.) | |
GG/GT | 321 | 60.9 | 301 | 57.1 | 1.17(0.91–1.49) | |||
Recessive | GT/TT | 453 | 86.0 | 484 | 91.8 | 0.002 | 1.00 (Ref.) | |
GG | 74 | 14.0 | 43 | 8.2 | 1.84(1.24–2.74) | |||
Alleles | T | 659 | 62.5 | 710 | 67.4 | 0.020 | 1.00 (Ref.) | |
G | 395 | 37.5 | 344 | 32.6 | 1.24 (1.03–1.48) | |||
DNMT3A | rs1550117 | |||||||
Codominant | AA | 10 | 1.9 | 25 | 4.7 | 0.034 | 1.00 (Ref.) | |
AG | 175 | 33.2 | 175 | 33.2 | 2.49 (1.16–5.35) | |||
GG | 342 | 64.9 | 327 | 62.0 | 2.61 (1.23–5.53) | |||
Dominant | AA/AG | 185 | 35.1 | 200 | 38.0 | 0.337 | 1.00 (Ref.) | |
GG | 342 | 64.9 | 327 | 62.0 | 1.13(0.88–1.46) | |||
Recessive | AA | 10 | 1.9 | 25 | 4.7 | 0.010 | 1.00 (Ref.) | |
AG/GG | 517 | 98.1 | 502 | 95.3 | 2.57 (1.22–5.41) | |||
Alleles | A | 195 | 18.5 | 225 | 21.3 | 0.102 | 1.00 (Ref.) | |
G | 859 | 81.5 | 829 | 78.7 | 1.20 (0.96–1.48) | |||
DNMT1 | rs2228611 | |||||||
Codominant | GG | 261 | 49.5 | 263 | 49.9 | 0.017 | 1.00 (Ref.) | |
AG | 242 | 45.9 | 218 | 41.4 | 1.12 (0.87–1.44) | |||
AA | 24 | 4.6 | 46 | 8.7 | 0.53 (0.32–0.90) | |||
Dominant | GG | 261 | 49.5 | 263 | 49.9 | 0.902 | 1.00 (Ref.) | |
AA/AG | 266 | 50.5 | 264 | 50.1 | 1.02 (0.80–1.30) | |||
Recessive | AA | 24 | 4.6 | 46 | 8.7 | 0.007 | 1.00 (Ref.) | |
AG/GG | 503 | 95.1 | 481 | 91.3 | 1.98 (1.19–3.20) | |||
Alleles | A | 290 | 27.5 | 310 | 29.4 | 0.334 | 1.00 (Ref.) | |
G | 764 | 72.5 | 744 | 70.6 | 1.09 (0.90–1.32) | |||
