Table 4 Stratified analysis of SNPs in a recessive model.
From: DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
SNPs | Group | Genotype | Work time with noise (years) | Expose level with noise (dB) | |||
|---|---|---|---|---|---|---|---|
≤16 | >16 | ≤85 | 85–92 | >92 | |||
rs7578575 | case | AA | 13 | 23 | 21 | 6 | 9 |
AT/TT | 212 | 279 | 219 | 95 | 177 | ||
control | AA | 15 | 21 | 20 | 6 | 7 | |
AT/TT | 227 | 264 | 212 | 85 | 194 | ||
P a | 0.848 | 0.909 | 0.960 | 0.341 | 0.503 | ||
Adjusted OR (95% CI)b | 0.95 (0.44–2.05) | 1.00 (0.54–1.86) | 1.03 (0.54–1.96) | 0.51 (0.17–1.54) | 1.38 (0.50–3.79) | ||
rs749131 | case | GG | 27 | 47 | 28 | 20 | 26 |
GT/TT | 198 | 255 | 212 | 81 | 160 | ||
control | GG | 22 | 21 | 15 | 11 | 17 | |
GT/TT | 220 | 264 | 217 | 83 | 184 | ||
P a | 0.305 | 0.002 | 0.050 | 0.122 | .0.084 | ||
Adjusted OR (95% CI)b | 1.37 (0.75–2.50) | 2.34 (1.36–4.03) | 1.97 (1.03–3.84) | 1.85 (0.82–4.17) | 1.77 (0.92–3.38) | ||
rs1550117 | case | AG/GG | 222 | 295 | 236 | 98 | 183 |
AA | 3 | 7 | 4 | 3 | 3 | ||
control | AG/GG | 232 | 270 | 220 | 91 | 191 | |
AA | 10 | 15 | 12 | 3 | 10 | ||
P a | 0.066 | 0.060 | 0.035 | 0.929 | 0.067 | ||
Adjusted OR (95% CI)b | 3.11 (0.84–11.48) | 2.41 (0.96–6.03) | 3.22 (1.02–10.16) | 1.17 (0.23–6.02) | 3.15 (0.85–11.65) | ||
rs2228611 | case | AG/GG | 218 | 285 | 226 | 96 | 181 |
AA | 7 | 17 | 14 | 5 | 5 | ||
control | AG/GG | 216 | 265 | 214 | 87 | 180 | |
AA | 26 | 20 | 18 | 7 | 21 | ||
P a | 0.001 | 0.489 | 0.406 | 0.469 | 0.002 | ||
Adjusted OR (95% CI)b | 4.05 (1.71–9.60) | 1.25 (0.64–2.47) | 1.31 (0.63–2.73) | 1.75(0.52–5.93) | 4.30 (1.58–11.70) | ||
