Figure 3
Whole-cell sensory transduction currents of Tg[PTmc1::Tmc2]; Tmc1∆/∆; Tmc2∆/∆ cochlear HCs at P6-7. (A) Families of representative sensory transduction currents recorded from cochlear HCs of genotypes indicated above. Hair bundles were deflected between 0.4 and 1.2 microns in 0.1-micron increments from both inner HCs and outer HCs of the apical turn. The scale bar applies to all families. (B) The currents of Tg[PTmc1::Tmc2]; Tmc1∆/∆; Tmc2∆/∆ inner HCs were not significantly different (paired t-test, P > 0.05) from those of Tmc1+/∆; Tmc2∆/∆ mice in apical and basal turns, in which only endogenous Tmc1 is expressed. In contrast, the currents of outer HCs were significantly smaller than those of Tmc1+/∆; Tmc2∆/∆ apical (paired t-test, P < 0.01) and basal (paired t-test, P < 0.001) cochlear turns. The number above each column and bar indicates the number of HCs examined.
