Figure 6

DPOAE amplitudes of transgenic mice. (A) Mean DPOAE amplitudes ( ± SD) of Tg[P_Tmc1::Tmc2]; Tmc1^∆/∆ (black line), Tmc1^∆/∆ (light gray line) and wild-type (Tmc1^+/+, dark gray line) mice at P16. The mean DPOAE amplitudes of Tg[P_Tmc1::Tmc2]; Tmc1^∆/∆ mice were significantly smaller than those of wild-type mice measured in response to f₂ stimuli ranging from 11.2 to 44.8 kHz (one-way ANOVA, P < 0.001) and were not significantly different from those of Tmc1^∆/∆ mice (one-way ANOVA, P > 0.05). (B) DPOAE amplitudes of Tg[P_Tmc1::Tmc1]; Tmc1^∆/∆ and wild-type mice at P16. The DPOAE amplitudes of Tg[P_Tmc1::Tmc1]; Tmc1^∆/∆ mice were not significantly different from those of wild-type mice except for the responses to the stimulus with f₂ = 19.2 kHz (Student’s t-test, P > 0.05). (C) DPOAE amplitudes of Tg[Tmc1^∆Ex8_9]; Tmc1^∆/∆ and Tmc1^∆/∆ mice at P16. The DPOAE amplitudes of Tg[Tmc1^∆Ex8_9]; Tmc1^∆/∆ mice were not significantly different from those of Tmc1^∆/∆ mice (Student’s t-test, P > 0.05). Dashed lines show background noise levels in all panels.