Figure 2
From: Identification of Urine Metabolites as Biomarkers of Early Lyme Disease
MetaboAnalyst results. MetaboAnalyst was used to identify pathways that were perturbed between (a) ELD versus HC using the 1,262 MF positive-ion mode metabolic biosignature, (b) ELD versus HC using the 228 MF negative-ion mode metabolic biosignature, (c) ELD versus MONO using the 1,601 MF included in positive-ion mode metabolic biosignature and (d) ELD versus MONO using the 320 MF negative-ion mode metabolic biosignature. The color and size of each circle is based on p-values and pathway impact values. The three top perturbed pathways based on p-values, pathway impact factor and largest number of unique masses associated with a pathway are numbered and correspond to 1. tryptophan metabolism, 2. glycerophospholipid metabolism, 3. vitamin B6 metabolism, 4. citrate cycle (TCA cycle), 5. tyrosine metabolism, 6. folate biosynthesis, 7. phenylalanine, tyrosine and tryptophan biosynthesis, 8. riboflavin metabolism and 9. biotin metabolism.
