Table 1 Association between HOTAIR expression and clinicopathological features of CCA.

From: Long non-coding RNA HOTAIR promotes tumorigenesis and forecasts a poor prognosis in cholangiocarcinoma

Clinicopathological features

No. of patients(n)

HOTAIR expression

p-value

High (n)

Low (n)

Gender

  Male

33

20

13

0.544

  Female

37

23

14

 

Age

  <60

32

21

11

0.624

  ≥60

38

22

16

 

Tumor site

  Intrahepatic

20

12

8

0.952

  Perihilar

22

13

9

 

  Distal

28

18

10

 

Tumor size

  <3

32

15

17

0.028

  ≥3

38

28

10

 

Vascular invasion

  Positive

30

20

10

0.468

  Negative

40

23

17

 

Lymph node invasion

  Present

31

20

11

0.805

  Absent

39

23

16

 

TNM stage

  I–II

26

11

15

0.021

  III–IV

44

32

12

 

Differentiation grade

  Well/moderately

25

14

11

0.609

  Poorly/undifferentiated

45

29

16

 

Postoperative recurrence

  Present

53

37

16

0.020

  Absent

17

6

11

 

Serum CEA level

  >5 ng/ml

42

25

17

0.804

  ≤5 ng/ml

28

18

10

 

Serum CA19-9 level

  >37 U/ml

46

27

19

0.609

  ≤37 U/ml

24

16

8

 

HBV infection

  Positive

21

12

9

0.789

  Negative

49

31

18

 
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