Figure 5 | Scientific Reports

Figure 5

From: Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos

Figure 5

The putative model of Xbra-Smad-1-mediated synergistic regulation of ventx1.1 transcriptional activation and neurogenesis inhibition in VMZ during early Xenopus development. The putative synergistic transcriptional activation of ventx1.1 (−180) promoter is regulated by the physical interaction of Smad-1 and Xbra in Xenopus embryos. BMP-4/Smad-1 and FGF/Xbra mediate a crosstalk in VMZ, inhibiting neurogenesis in a Ventx1.1-dependent manner during embryonic development of Xenopus.

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