Table 4 Association between treatment with phosphate-binders and all-cause mortality.

From: Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study

PS-adjusted model

All-cause mortality

HR (95% CI)

P-value

Unadjusted model (n = 2926)

0.38 (0.32–0.46)

<0.001

Multivariable-adjusted model (n = 2926)

0.75 (0.60–0.93)

0.009

PS-adjusted model

   PS-matched model (1:1, n = 928)

0.74 (0.57–0.96)

0.022

   PS-stratification (n = 2926)

0.74 (0.58–0.96)

0.021

   PS-adjusted regression model (n = 2926)

0.74 (0.59–0.92)

0.006

   IPTW model (n = 2926)

0.69 (0.53–0.91)

0.007

  1. The HR was estimated using Cox proportional hazard model. In the multivariable model, age, sex, presence of diabetes mellitus and comorbidity, dialysis history, dialysis time per session, Kt/V for urea, normalized protein catabolic rate, body mass index, cardiothoracic ratio, systolic blood pressure, blood hemoglobin level, serum levels of urea nitrogen, creatinine, albumin, total cholesterol, C-reactive protein, corrected calcium, phosphate, alkaline phosphatase, and parathyroid hormone, and use of erythrocyte stimulating agents, anti-hypertensives, and vitamin D receptor activators were included. PS was created by logistic regression analysis using all the parameters listed here. A two-tailed P-value less than 0.05 was considered statistically significant. Abbreviations: CI, confidence interval; HR, hazard ratio; IPTW, inverse probability of treatment weighting; PS, propensity score.
Back to article page