Figure 7
Microbial composition of faecal samples at Day 7 from DSS-treated mice. (A) Species richness (measured by chao1), n = 5/group. (B) Shannon’s diversity (H′), n = 5/group. (C) Non-metric multidimensional scaling (NMDS) plot of the Bray-Curtis resemblance matrix following square-root transformation of relative abundance data showing the impact of DSS on the overall microbial composition, confirmed by pair-wise PERMANOVA (Control vs DSS): t = 3.34, p = 0.01, permutations = 999, n = 15/group (with and without nesting for vitamin D subgrouping). (D) Relative abundance (%) of Sutterella OTU174 between control and DSS mice (LDA 4.27, P < 0.0001), p-value derived from Linear discriminant analysis effect size (LEfSe), n = 15/group. (E) NMDS plot of the Bray-Curtis resemblance matrix following square-root transformation of relative abundance data demonstrating a significant shift of the control D++ microbial composition (green) towards that of the DSS group, n = 5/group. ***P < 0.001.
