Table 3 Top 10% targets in module 7 ranking by TI and relevant compounds.

PRKCA

P17252

1.000

Protein kinase C alpha type

Glycerol monolinoleate^§

SR

Glyceromonooleate^§

SR

Mandenol^§

SR

MAPK3

P27361

0.940

Mitogen-activated protein kinase 3

Chrysin

AMR

PRKACA

P17612

0.834

cAMP-dependent protein kinase catalytic subunit alpha

Adenosine

AR, AMR

EGFR

P00533

0.685

Epidermal growth factor receptor

Quercetin^§

AR

Caffeic acid^§

AR

Tectochrysin^§

AR

NFKB1

P19838

0.617

Nuclear factor NF-kappa-B p105 subunit

Psoralen^§

SR

AKT1

P31749

0.612

RAC-alpha serine/threonine-protein kinase

Quercetin^§

AR

GNAI3

P08754

0.610

Guanine nucleotide-binding protein G(k) subunit alpha

2-octanone

SR

CALM1

P0DP23

0.597

Calmodulin-1

Chrysin^§

AMR

RAC1

P63000

0.592

Ras-related C3 botulinum toxin substrate 1

Guanosine

AR

ADCY5

O95622

0.584

Adenylate cyclase type 5

Adenosine

AR, AMR

RHOA

P61586

0.554

Transforming protein RhoA

Naringeninic acid

AR

CAMK2A

Q9UQM7

0.551

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Ferulic acid

AR

NRAS

P01111

0.544

GTPase NRas

Ononin

AR

HRAS

P01112

0.544

GTPase HRas

Isoquercitrin

AR

HDAC1

Q13547

0.519

Histone deacetylase 1

Naringeninic acid^§

AR

PLCG2

P16885

0.518

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Glyceromonooleate

SR

CREB1

P16220

0.515

Cyclic AMP-responsive element-binding protein 1

Oroxylin A^§

AR

Chrysin^§

AMR

Wogonin^§

SR

Tectochrysin^§

SR

GNAO1

P09471

0.512

Guanine nucleotide-binding protein G(o) subunit alpha

2-octanone

SR

CAMK2B

Q13554

0.511

Calcium/calmodulin-dependent protein kinase type II subunit beta

Isorhamnetin^§

AR

Quercetin^§

AR

RXRA

P19793

0.504

Retinoic acid receptor RXR-alpha

Guanosine

AR