Table 1 List of genes with top 10% betweenness centrality (BC) scores in the network.

From: Transcriptome profiling of whisker follicles in methamphetamine self-administered rats

Rank

Genes

Genbank

BC

Addic Re.

Group

Description

Normalised

MASA

WD

1

Hsp90ab1

NM_001004082

0.2127

O

G4

Heat shock protein 90 alpha (cytosolic), class B member 1 (Hsp90ab1)

0.94

0.51

2

Akt1

NM_033230

0.1694

O

G2

V-akt murine thymoma viral oncogene homolog 1 (Akt1)

1.58

0.80

3

Src

NM_031977

0.1171

O

G2

SRC proto-oncogene, non-receptor tyrosine kinase (Src)

1.31

0.66

4

Ranbp2

NM_001191604

0.0671

 

G5

RAN binding protein 2 (Ranbp2)

0.77

1.39

5

Mapk14

NM_031020

0.0586

 

G4

Mitogen activated protein kinase 14 (Mapk14)

0.96

0.58

6

Egfr

NM_031507

0.0568

 

G2

Epidermal growth factor receptor (Egfr)

1.30

0.67

7

Prkacb

XM_006233452

0.0447

O

G2

Protein kinase, cAMP dependent, catalytic, beta (Prkacb), transcript variant X2

1.23

0.65

8

Gnb2l1

NM_130734

0.0436

 

G6

Guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 (Gnb2l1)

0.78

0.45

9

Cav1

NM_031556

0.0419

 

G2

Caveolin 1, caveolae protein (Cav1), transcript variant 1

3.53

0.52

10

Cdh1

NM_031334

0.0385

O

G4

Cadherin 1 (Cdh1)

1.04

0.50

11

Cct7

NM_001106603

0.0363

 

G6

Chaperonin containing Tcp1, subunit 7 (eta) (Cct7)

0.85

0.54

12

Itgb1

NM_017022

0.0322

 

G2

Integrin, beta 1 (Itgb1)

2.02

1.16

13

Ppp1ca

NM_031527

0.0319

O

G6

Protein phosphatase 1, catalytic subunit, alpha isozyme (Ppp1ca)

0.81

0.50

14

Actr1a

NM_001106364

0.0313

 

G4

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) (Actr1a)

0.99

0.51

15

Tgfb1

NM_021578

0.0313

O

G2

Transforming growth factor, beta 1 (Tgfb1)

1.75

0.34

16

Sec61a1

NM_199256

0.0290

O

G6

Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1)

0.73

0.31

17

Cdk16

NM_031077

0.0274

 

G6

Cyclin-dependent kinase 16 (Cdk16), transcript variant 2

0.85

0.51

18

Ywhab

NM_019377

0.0262

O

G6

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta (Ywhab)

0.76

0.52

19

Sdc2

NM_013082

0.0250

 

G2

Syndecan 2 (Sdc2)

1.77

0.67

20

Psmd2

NM_001031639

0.0236

 

G6

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (Psmd2)

0.77

0.45

21

Jak1

NM_053466

0.0232

 

G2

Janus kinase 1 (Jak1)

1.83

1.05

22

Rela

NM_199267

0.0232

 

G4

V-rel avian reticuloendotheliosis viral oncogene homolog A (Rela)

1.04

0.56

23

Vcp

NM_053864

0.0218

O

G6

Valosin-containing protein (Vcp)

0.78

0.51

24

Srebf2

NM_001033694

0.0211

 

G4

Sterol regulatory element binding transcription factor 2 (Srebf2)

0.94

0.55

25

Atp5a1

NM_023093

0.0206

 

G6

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (Atp5a1)

0.79

0.44

26

Nrp1

NM_145098

0.0201

O

G2

Neuropilin 1 (Nrp1)

1.87

0.63

27

App

NM_019288

0.0197

O

G2

Amyloid beta (Aβ) precursor protein (App)

2.71

0.83

28

Eef1g

NM_001004223

0.0197

O

G6

Eukaryotic translation elongation factor 1 gamma (Eef1g)

0.77

0.33

29

Stat5a

NM_017064

0.0191

 

G2

Signal transducer and activator of Transcription 5A (Stat5a)

2.18

0.64

30

Itch

NM_001005887

0.0187

 

G2

Itchy E3 ubiquitin protein ligase (Itch)

1.22

0.87

31

Atp1a1

NM_012504

0.0183

 

G2

ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1)

1.80

0.63

32

Zmiz1

NM_001108393

0.0176

 

G2

Zinc finger, MIZ-type containing 1 (Zmiz1)

1.72

0.68

33

Gli1

NM_001191910

0.0161

 

G2

GLI family zinc finger 1 (Gli1)

3.78

1.42

34

Prkg2

NM_013012

0.0158

O

G6

Protein kinase, cGMP-dependent, type II (Prkg2)

0.51

0.09

35

Ctbp2

NM_053335

0.0153

 

G2

C-terminal binding protein 2 (Ctbp2)

1.24

0.92

36

Hadhb

NM_133618

0.0147

O

G6

Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (Hadhb)

0.69

0.48

37

Nfkb2

NM_001008349

0.0144

 

G2

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 (Nfkb2)

1.57

0.85

38

Stk11

NM_001108069

0.0143

 

G6

Serine/threonine kinase 11 (Stk11)

0.82

0.43

39

Vcl

NM_001107248

0.0141

 

G2

Vinculin (Vcl)

1.73

0.73

40

Pip4k2b

NM_053550

0.0136

O

G2

Phosphatidylinositol-5-phosphate 4-kinase, type II, beta (Pip4k2b)

1.46

0.74

41

Tle3

NM_053400

0.0134

O

G6

Transducin-like enhancer of split 3 (Tle3)

0.70

0.35

42

Map3k3

NM_001107058

0.0133

 

G2

Mitogen activated protein kinase (Map3k3)

1.41

0.72

43

Fbxw11

NM_001106993

0.0129

 

G2

F-box and WD repeat domain containing 11 (Fbxw11)

1.16

0.68

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