Table 1 Antimicrobial activity of gomesin peptides from A. gomesiana (AgGom) and H. infensa (HiGom) against a range of Gram-positive and Gram-negative bacteria.

From: Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

 

MIC (μM)

MBC (μM)

AgGom

HiGom

AgGom

HiGom

Gram-positive bacteria

Staphylococcus aureus ATCC 25923

>28

28

>28

28

Enterococcus faecalis ATCC 51299 VanB

28

14

28

14

Enterococcus faecalis Van A

7

3.5

7

7

Bacillus subtilis ATCC 6633

0.875

0.656

0.875

0.875

Bacillus megaterium ATCC 13632

≤0.014

≤0.014

≤0.014

≤0.014

Streptococcus pneumoniae ATCC 33400

>28

>28

>28

>28

Staphylococcus aureus ATCC 43300 MRSA

>28

>28

>28

>28

Staphylococcus aureus ATCC 29213 MRSA

>28

>28

>28

>28

Staphylococcus epidermidis GISA

14

7

14

7

Gram-negative bacteria

Escherichia coli ATCC 25922

14

14

14

14

Klebsiella pneumonia ATCC 700603

>28

28

>28

28

Klebsiella pneumoniae ATCC 13883

14

7

14

7

Pseudomonas aeruginosa ATCC 10145

>28

>28

>28

>28

  1. MIC = minimal inhibitory concentration. MBC = minimal bactericidal concentration. Three independent experiments were performed, each in triplicates.