Figure 1 | Scientific Reports

Figure 1

From: GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation

Figure 1

GRK2 knockdown alters kidney morphometry and reduces glomerular filtration rate (GFR). (a) Representative images of right and left kidneys from 1.5-, 3- and 6-month-old shGRK2 and age-matched C57Bl/6 mice. (b) Mean ± S.E.M of kidney mass (right & left) relative to tibia length of shGRK2 and C57Bl/6 mice at 1.5, 3 and 6 months of age (n = 6). (c) Mean ± S.E.M of organ mass (heart, lungs, kidneys, and liver) relative to body weight in 3-month-old shGRK2 and age-matched C57Bl/6 mice (n = 6). (d) Mean ± S.E.M of glomerular filtration rate (GFR) measured by FITC-inulin clearance in 6-month-old shGRK2 and age-matched control C57Bl/6 mice (n = 6). * denotes significantly different at (p < 0.05, unpaired Student’s t test).

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