Figure 5 | Scientific Reports

Figure 5

From: GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation

Figure 5

ROS production and glomerular injury are exacerbated in shGRK2 mice. Mean ± S.E.M for renal cortex levels (nmol/µmol) of (a) ethidium (Eth) and (b) 2-hydroxydihydroethidium (2OH-Eth) after incubation with dihydroethidium (DHE) and separation by high-performance liquid chromatography (HPLC). Eth and 2OH-Eth levels were normalized to dihydroethidium (DHE) levels. (c) Representative images of Periodic-Acid Schiff stained glomerulus from 6-month-old shGRK2 and age-matched C57Bl/6.Scale bar is 20 µm. Mean ± S.E.M of the glomerular injury score based on mesangial matrix area done by trained pathologist in blinded manner (n = 6). * denotes significantly different at (p < 0.05, unpaired Student’s t test).

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