Figure 3 | Scientific Reports

Figure 3

From: RETRACTED ARTICLE: Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo

Figure 3

(A) Expression of apoptotic proteins in T98G cells at 36 hours after infection with NDV-LaSota at 0, 0.1, 1 and 10 MOI increased in a dose-dependent manner. β-Tubulin was used as a control. (B) In T98G cells, the AKT/mTOR pathway was inhibited as the MOI of NDV was increased, and AMPK was significantly activated. (C,D) Time course showing the induction of cell death in relation to AKT and AMPK signaling after NDV infection. (E) Viral RNA levels in the medium relative to those from HEB cells (****P < 0.0001, n = 3).

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