Figure 5 | Scientific Reports

Figure 5

From: Addition of dairy lipids and probiotic Lactobacillus fermentum in infant formula programs gut microbiota and entero-insular axis in adult minipigs

Figure 5

Significant correlations between gut microbiota composition, luminal metabolites and host entero-insular axis parameters. Within the gut microbiota, the three genera Flavonifractor, Lachnoclostridium and Hungatella were positively correlated. They all belong to the Clostridia class, including SCFA-producing bacteria. These genera were also positively correlated to plasma GLP-1 secretory response to meal stimulation. Plasma GLP-1 secretory response to meal stimulation was, as expected, positively associated with luminal SCFA concentrations, specifically propionate. The percentage of caecal GLP-1 secreting-cells amongst enteroendocrine cells was positively correlated to the caecal GLP-1 content, to the plasma GLP-1 secretory response to meal stimulation and to the pancreatic endocrine tissue, in accordance with the well-known trophic effect of GLP-1 on β cells. These results highlight potential mechanisms between bacteria composition and metabolism, and host metabolism. GLP-1, Glucagon-like peptide-1; SCFA, short-chain fatty acid; C3, propionate. R > |0.50| and p < 0.05. In bold: significant effect of the infant formula composition.

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