Figure 7
Schematic diagrams of α1 Na/K-ATPase-mediated Src regulation in normal and cancer cells. Established signaling pathways are denoted by solid black arrows and speculated signaling pathways are denoted by broken black arrows. NKA = Na/K-ATPase, Cav = Caveolin 1, FAK = Focal Adhesion Kinase, RTK = Receptor Tyrosine Kinase, PI3K = Phosphatidyl Inositol 3 Kinase, ROS = Reactive Oxygen Species, PLC = Phospholipase C, PKC = Protein Kinase C, PKM2 = Pyruvate Kinase isoenzyme M2, PDH = Pyruvate Dehydrogenase, ERK = Extracellular Regulatory Kinase. The circled letter P denotes phosphorylation and activation.
