Figure 5
Protein-protein interaction networks of the differentially expressed tear proteins of hard CL users. The major interaction networks of differentially expressed tear proteins obtained by IPA analysis (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis)78 in hard CL users (a) before and (b) after CL discontinuation. Red and green shading indicate up- and down-regulation of the proteins, respectively. Nodes (proteins) depicted with different shapes represent functional protein classes (e.g. enzymes or transmembrane receptors) and, the colours red and green represent increment and decrement of protein abundance, respectively, with different colour intensities that correspond to the degree of expression. The intensity of the node colour indicates the degree of differential regulation.
