Figure 1
Sequence alignment of 1-Cys Prx from A. fumigatus, other fungi and mammals. Identical residues among sequences are depicted in blue. The yellow box denotes the conserved motif PVCPTTE in the Prx6 sub-class. The colored arrowheads indicate the conserved amino acids of the catalytic triad: Thr (red), CP (orange) and Arg (blue). The colored bars denote the mitochondria signal peptide (red), residues insertions (green) or deletions (orange). The secondary structure assignments based on the structure of H. sapiens Prx6 (PDB code: 1PRX) are shown below the amino acid sequences. The species abbreviation initials are given in italics and are as follows: Af_prx1 = A. fumigatus prx1 (AFUB_065670); Af_prxB = A. fumigatus prxB (AFUB_062560); Af_prxC = A. fumigatus prxC (AFUB_080670); Sc_Prx1 = S. cerevisiae Prx1 (NP_009489.1); Al_Prx1 = A. lentulus Prx1 (GAQ08014.1); An_Prx1 = A. nidulans 1-Cys peroxiredoxin (CBF85378.1); Ca_Prx1 = Candida albicans putative Prx1 (XP_716935.1); Cn_Prx1 = Cryptococcus neoformans Prx (XP_567781); Df_Prx1 = Debaryomyces fabryi Prx (XP_015465609.1); Mo_Prx1 = Magnaporthe oryzae mitochondrial peroxiredoxin Prx1 (XP_003715830.1); Um_Prx1 = Ustilago maydis Prx (XP_011392689); Hs_Prx6 = Homo sapiens Prx6 (NP_004896.1); Bt_Prx6 = Bos taurus Prx6 (NP_777068.1); Mm_Prx6 = Mus musculus Prx6 (NP_031479.1); Rn_Prx6 = Rattus norvegicus Prx6 (NP_446028.1); Ss_Prx6 = Sus scrofa Prx6 (NP_999573.1).
