Figure 10 | Scientific Reports

Figure 10

From: Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to H2O2 metabolism and virulence

Figure 10

A. fumigatus Prx1, but not PrxB or PrxC contributes to virulence in a mouse model of invasive pulmonary aspergillosis. (A,B) Comparative analysis of wild-type and 1-Cys Prx mutant strains in a neutropenic murine model. No mock infected animals perished in either experiment. Survival of the mutant strain was compared to that of the wild-type and complemented strain. Infection experiments were repeated two times with similar results. Survival curves between the Δprx1 mutant and wild-type strain and mutant and reconstituted strains were statistically significant (*p ≤ 0.0132 and p ≤ 0.0074, respectively). No significant difference was observed between the wild-type and ΔprxB or ΔprxC deletion strains. Phagocytosis index (C) and killing activity (D) is increased in the A. fumigatus Δprx1 mutant strain. The results are expressed as means ± SD for three independent experiments. *p ≤ 0.05 compared to wild-type; #p ≤ 0.05 compared to the complemented strain.

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