Table 1 Liver function parameters measured in the serum before and after treatment.

From: Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

Liver function parameters

UDCA (n = 9)

Vitamin E (n = 10)

Pre-dose

Week 4

Week 8

P-value

Pre-dose

Week 4

Week 8

P-value

Alanine aminotransferase (IU/L)

81.56 ± 11.63

48.67 ± 8.07

57.67 ± 12.56

†

80.7 ± 9.5

56.6 ± 10.1

50 ± 9

†,‡

Aspartate aminotransferase (IU/L)

42.22 ± 4.24

27.89 ± 3.49

35.22 ± 7.59

†

45.1 ± 6.3

33.7 ± 5.5

30.9 ± 3.6

†,‡

Gamma-glutamyl transferase (IU/L)

87 ± 18

66.56 ± 12.59

64.11 ± 12.01

†,‡

60.6 ± 14.2

47.1 ± 7.9

47.1 ± 9.0

‡

miR-122 (fold change)

1.00 ± 0.00

0.6078 ± 0.5740

0.5733 ± 0.6330

†,‡

1.00 ± 0.00

0.738 ± 0.514

1.073 ± 0.933

ns

  1. Data are the mean ± standard deviation. †P < 0.05 (Friedman test) between pre-dose and week 4; ‡P < 0.05 between pre-dose and week 8. ns, not significant.
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