Table 3 Univariable and multivariable analyses of factors associated with development of acute kidney injury (KDIGO stage 1).
From: Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment
Variable | Univariable analysis | Multivariable analysis* | ||
|---|---|---|---|---|
sHR (95% CI) | p | sHR (95% CI) | p | |
Age in years | 1.02 (0.98–1.04) | 0.046 | ||
Male gender | 0.86 (0.54–1.36) | 0.51 | ||
Diabetes mellitus | 1.35 (0.84–2.17) | 0.22 | ||
Chronic renal failure | 1.64 (0.93–2.9) | 0.09 | ||
Severe hepatic failure | 0.40 (0.13–1.25) | 0.11 | ||
Solid neoplasms | 0.64 (0.34–1.21) | 0.17 | ||
Hematological malignancies | 0.75 (0.38–1.49) | 0.42 | ||
Causative agent of BSI | 0.26 | |||
Enterobacteriaceae | 1 (Reference) | |||
Pseudomonas spp. | 1.31 (0.69–2.50) | |||
Acinetobacter spp. | 1.78 (1.03–3.07) | |||
Enterobacteriaceae plus Pseudomonas spp. | 1.79 (0.66–4.83) | |||
Enterobacteriaceae plus Acinetobacter spp. | 0.74 (0.12–4.53) | |||
Polymicrobial BSI | 0.84 (0.48–1.46) | 0.53 | ||
Colistin susceptibility test method | 0.85 | |||
Vitek 2 | 1 (Reference) | |||
Etest | 1.05 (0.63–1.73) | |||
ICU stay | 1.00 (0.60–1.68) | 0.99 | ||
Presence of central venous catheter | 0.70 (0.41–1.19) | 0.18 | ||
Presence of septic shock | 1.07 (0.66–1.73) | 0.79 | ||
Neutropenia | 0.33 (0.11–1.02) | 0.054 | 0.40 (0.13–1.26) | 0.12 |
Serum hemoglobin in g/dl | 1.05 (0.86–1.29) | 0.62 | ||
Serum total bilirubin in mg/dl | 1.00 (0.95–1.05) | 0.88 | ||
Serum creatinine in mg/dl | 1.17 (0.96–1.42) | 0.13 | ||
Serum albumin<2.5 g/dl | 1.99 (1.26–3.14) | 0.003 | 1.85 (1.17–2.93) | 0.009 |
Type of adequate therapy | 0.93 | |||
Colistin monotherapy | 1 (Reference) | |||
2 active agents including colistin | 1.04 (0.65–1.66) | |||
3 active agents including colistin | 0.87 (0.36–2.14) | |||
Time to adequate therapy in days | 1.03 (0.95–1.12) | 0.44 | ||
9 MU colistimethate loading-dose | 0.88 (0.56–1.38) | 0.58 | ||
Use of other nephrotoxic agents | 1.08 (0.51–2.31) | 0.84 | ||
