Figure 1
From: Patient stratification in clinical glaucoma trials using the individual tear proteome
Outline and results from the patient stratification. The top row explains the outline of data processing, protein clustering and patient stratification. The heat maps visualize the change in protein expression between baseline and time points after the medication switch. V refers to visits and focus is on the V1-V5 comparison. Two protein clusters associated with pro-inflammation are indicated in grey rows, and proteins linked to ocular surface protection in white rows. The differences between the patient groups become clearer with time, as is visualized by the additional heat maps (V1-V2, V1-V3 and V1-V4) showing expression differences in comparison to baseline. Two patients were excluded due to missing baseline expression and in addition, two patients had no V4 data. ALB, albumin; C3, complement C3; ENO1, alpha-enolase; LPO, lactoperoxidase; LYZ, lysozyme; PROL1, proline-rich protein 1; TF, serotransferrin.
