Table 1 Changes in clinical signs between baseline and the visits after medication switch.

From: Patient stratification in clinical glaucoma trials using the individual tear proteome

Clinical sign

Baseline values

Change from baseline

1.5 months

3 months

6 months

12 months

Conjunctival redness

Mean

1.750

−0.286

−0.607

−0.75

−0.964

95% CI

[1.459, 2.041]

[−0.541, −0.03]

[−0.873, −0.341]

[−1.022, −0.478]

[−1.188, −0.741]

Pa

 

0.04*

<0.001***

<0.001***

<0.001***

Lid redness

Mean

0.857

−0.357

−0.214

−0.464

−0.519

95% CI

[0.605, 1.109]

[−0.574, −0.14]

[−0.48, 0.052]

[−0.733, −0.196]

[−0.836, −0.201]

Pa

 

0.004**

0.12

0.003**

0.005**

Fluorescein tear break-up time

Mean

5.393

1.786

2.179

3.214

4.444

95% CI

[4.284, 6.501]

[0.453, 3.118]

[0.735, 3.622]

[1.531, 4.897]

[2.184, 6.705]

Pb

 

0.01*

0.005**

<0.001***

<0.001***

Corneal staining

Mean

0.607

−0.429

−0.357

−0.286

−0.393

95% CI

[0.252, 0.963]

[−0.785, −0.072]

[−0.741, 0.026]

[−0.732, 0.16]

[−0.792, 0.007]

Pa

 

0.02*

0.08

0.25

0.06

Conjunctival staining (nasal)

Mean

1.393

−0.25

−0.286

−0.393

−0.179

95% CI

[1.070, 1.715]

[−0.654, 0.154]

[−0.633, 0.062]

[−0.806, 0.02]

[−0.614, 0.257]

Pa

 

0.31

0.12

0.07

0.53

Conjunctival staining (temporal)

Mean

1.571

−0.321

−0.393

−0.464

−0.357

95% CI

[1.265, 1.878]

[−0.656, 0.013]

[−0.819, 0.034]

[−0.852, −0.077]

[−0.755, 0.041]

Pa

 

0.07

0.07

0.02*

0.08

Schirmer’s test

Mean

12.000

4.214

4.964

4.786

5.429

95% CI

[8.511, 15.489]

[1.987, 6.441]

[1.349, 8.579]

[1.288, 8.283]

[2.622, 8.236]

Pb

 

<0.001***

0.009**

0.009**

<0.001***

  1. CI, confidence interval.
  2. *P < 0.05; **P < 0.01; ***P < 0.001; a2-group Wilcoxon Signed Rank Test; bPaired t-test.
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