Table 2 Changes in clinical symptoms between baseline and the visits after medication switch.

Irritation, burning, stinging

Mean

1.143

−0.071

−0.179

−0.143

−0.143

95% CI

[0.629, 1.657]

[−0.738, 0.595]

[−0.855, 0.498]

[−0.849, 0.563]

[−0.737, 0.451]

P^a

0.73

0.65

0.61

0.66

Itching

Mean

1.821

−0.643

−0.821

−0.643

−0.75

95% CI

[1.361, 2.282]

[−1.14, −0.145]

[−1.339, −0.304]

[−1.162, −0.124]

[−1.284, −0.216]

P^a

0.02*

0.007**

0.02*

0.01*

Foreign body sensation

Mean

1.571

−0.786

−1

−0.964

−0.393

95% CI

[1.061, 2.082]

[−1.328,−0.244]

[−1.615, −0.385]

[−1.497, −0.432]

[−1.055, 0.269]

P^a

0.008**

0.009**

0.003**

0.30

Tearing

Mean

1.893

−0.929

−1.036

−1.393

−1

95% CI

[1.321, 2.464]

[−1.466, −0.391]

[−1.673, −0.398]

[−1.934, −0.851]

[−1.517, −0.483]

P^a

0.004**

0.009**

<0.001***

0.002**

Dry eye sensation

Mean

2.071

−0.357

−0.536

−0.679

−0.607

95% CI

[1.555, 2.588]

[−0.855, 0.14]

[−0.951, −0.12]

[−1.247, −0.11]

[−1.294, 0.08]

P^a

0.16

0.03*

0.03*

0.09