Figure 2

(a) PCA score plot visualizing changes in the metabolomic profile of the mouse retina. The black, red, blue and green symbols indicate control (Ctrl), nerve crush (NC) day 2, NC day 4 and NC day 7 sample groups, respectively. (b) OPLS-DA score plot visualizing changes in the metabolomic profile of the retina in the above 4 groups. (c) OPLS-DA score plot visualizing changes in the metabolomic profile of the mouse retina in the Ctrl and NC day 2 groups. (d) S-plot analysis of OPLS-DA data to extract features profiles of the retina in the Ctrl and NC day 2 groups. Features higher in the NC day 2 group are described by the following area: 0 < p[1], p(corr)[1] < 1. Features lower in the NC day 2 group are described by the following area: −1 < p[1], p(corr)[1] < 0. The red lines indicate correlation values (p(corr)[1]P) greater than 0.6 (up to 1.0) and less than −0.55 (as low as −1.0) for the selected features.