Table 1 Characteristics of the Studies Comparing Peripheral Cytokine Levels Between Elderly with and without Depression Included in the Meta-analysis.
Author, year | Country | Peripheral pro-Inflammatory markers | Criteria for Depression | Sample size (N) (Depression/Controls) | Proportion of female gender (%) (Dementia/Controls) | Mean age (years) (Dementia/Controls) | Newcastle-Ottawa Scale Score (Maximum score = 9) |
|---|---|---|---|---|---|---|---|
Forti, 2010 64 | Italy | IL-6, TNF-a, CRP | DSM-IV and ≥10 on GDS | 93/870 | 74.2/52.9 | 81.4/ 73.8 | 7 |
Diniz, 2010 54 | Brazil | IL-1b | MDD on SCID | 23/44 | 82.6/86.4 | 70.2 /69.5 | 5 |
Thomas, 200556 | UK | IL-1b, CRP | DSM-IV and ≥20 on Montgomery-Asberg DRS | 19/21 | 68.4/57.1 | 76.4 /74.9 | 6 |
Torres, 201457 | Brazil | IL-1b, IL-6 | DSM-IV, GDS, MINI-plus | 13/18 | 61.5/50.0 | 74/ 83 | 5 |
Dimopoulos, 200762 | Greece | IL-6 | DSM-IV and ≥10 on GDS | 33/33 | 60.6 /60.6 | 65.8 / 65.4 | 7 |
Milaneschi, 200855 | Italy | IL-1b, IL-6, TNF-a, CRP | ≥20 CES-D | 213/778 | 75.1/ 50.6 | 77.5 / 74.3 | 7 |
Elderkin-Thompson, 201263 | US | IL-6, CRP | MDD on SCID and 15/17 on Hamilton DRS | 42/45 | 66.7/75.6 | 69.7 / 69.2 | 5 |
Vogelzangs, 201467 | Netherlands | IL-6, CRP | DSM-IV and CIDI | 358/131 | 66.2 / 61.1 | 70.6/ 70.1 | 6 |
Charlton, 201853 | US | IL-1b, IL-6, TNF-a | MDD on SCID and 15/17 on Hamilton DRS | 24/34 | 66.7/ 61.7 | 67.2/ 70.2 | 6 |
Pennix, 200366 | US | IL-6, TNF-a, CRP | ≥16 CES-D | 145/2879 | 61.4 /51.0 | 74.0 /73.6 | 6 |
Nadrowski, 201665 | Poland | IL-6, CRP | >6 on GDS | 1095/2423 | Data not provided | Data not provided | 7 |
Marinho, 201273 | Brazil | TNF-a | ≥6 on GDS | 3/50 | Data not provided | Data not provided | 6 |
Bremmer, 200877 | Netherlands | CRP | ≥16 CES-D | 38/1094 | 47.3/73.7 | 75.2/75.9 | 6 |
Kop, 200278 | United States | CRP | >10 CES-D | 510/3750 | Data not provided | Data not provided | 6 |
