Table 2 Characteristics of the Studies Comparing Peripheral Cytokine Levels Between Elderly with and without Dementia Included in the Meta-analysis.
Author, year | Study Country | Peripheral pro-Inflammatory markers | Criteria for dementia | Sample size (N) (Dementia/Controls) | Proportion of female gender (%) (Dementia/Controls) | Mean age (years) (Dementia/Controls) | Newcastle-Ottawa Scale Score (Maximum score = 9) |
|---|---|---|---|---|---|---|---|
De Luigi, 200158 | Switzerland | IL-1b | NINCDS-ADRDA | 12/43 | Data not provided | Data not provided | 5 |
Zuliani, 200759 | Italy | IL-1b, IL-6, TNF-a | NINCDS-ADRDA | 60/42 | 65.0 /46.0 | 78.5/ 72.5 | 6 |
Yasutake, 200641 | Japan | IL-1b, TNF-a | NINCDS-ADRDA | 60/33 | 66.7/ 75.8 | 77.9/ 71.1 | 5 |
Kalman, 199768 | UK | IL-6 | NINCDS-ADRDA | 26/24 | 65.4 / 75.0 | 75.4 /72.9 | 5 |
Villarreal, 201660 | Panama | IL-1b, IL-6, TNF-a, CRP | NINCDS-ADRDA | 28/77 | 78.6/ 64.9 | 81.9/ 76.5 | 7 |
Torres, 201457 | Brazil | IL-1b, IL-6 | NINCDS-ADRDA | 35/18 | 71.4 / 50.0 | 81.0/ 83.0 | 5 |
Ciabattoni, 200769 | Italy | IL-6, TNF-a, CRP | NINCDS-ADRDA | 44/44 | 56.8 / 61.4 | 73.0/ 75.0 | 5 |
Uslu, 201270 | Turkey | IL-6, TNF-a | NINCDS-ADRDA | 28/23 | 64.3 / 56.5 | 68.4/ 66.2 | 5 |
Huang, 201371 | Taiwan | IL-6, TNF-a | DSM-IV | 28/19 | 14.3 / 26.3 | 83.0 / 79.9 | 5 |
Alvarez, 200774 | Spain | TNF-a | NINCDS-ADRDA | 141/30 | 70.2 / 66.7 | 75.3 / 68.9 | 5 |
Bonotis, 200872 | Greece | IL-6, TNF-a | NINCDS-ADRDA | 19/21 | 57.9 / 52.4 | 75.1/ 71.2 | 5 |
Mulder, 2010 79 | Netherlands | CRP | NINCDS-ADRDA | 140/30 | 55.0 / 57.0 | 66.0/ 65.0 | 7 |
O’Bryant, 2010 80 | US | CRP | NINCDS-ADRDA | 192/174 | 50.0 / 63.2 | 75.8/ 70.7 | 6 |
Lawlor, 199681 | Ireland | CRP | NINCDS-ADRDA | 17/15 | 70.6/ 80.0 | 74.9/ 68.5 | 5 |
Yarchoan, 201387 | US | CRP | NINCDS-ADRDA | 203/117 | 58.0 / 63.0 | 74.5/ 69.9 | 8 |
Lepara, 200982 | Yugoslavia | CRP | NINCDS-ADRDA | 30/30 | 80.0 / 73.3 | 80.0 /77.5 | 5 |
Mancinella, 200983 | Italy | CRP | NINCDS-ADRDA | 34 99 | 58.0 / 65.0 | 83.4/ 83.0 | 5 |
Davis, 200984 | Trinidad and Tobago | CRP | NINCDS-ADRDA | 18/51 | Data not provided | Data not provided | 5 |
Solerte, 200075 | Italy | TNF-a | NINCDS-ADRDA | 22/15 | Data not provided | 76.5 /77.0 | 5 |
Hsu, 201785 | Taiwan | CRP | ICD-9 | 260 /1176 | 51.9 /48.0 | 74.1/ 73.0 | 7 |
Licastro, 200086 | Italy | CRP | NINCDS-ADRDA | 145/51 | 62.8 /60.8 | 75.0/ 78.0 | 5 |
Laske, 201176 | Germany | TNF-a | NINCDS-ADRDA | 45/30 | Data not provided | Data not provided | 5 |
Forlenza, 200961 | Brazil | IL-1b | NINCDS-ADRDA | 58/31 | 82.8/ 64.5 | 76.3/ 69.9 | 5 |
