Table 2 AEIin rats: Grading of ocular lesions was done as per OECD 405 grading guidelines.
Sl no | Animal species | Capsaicin treatment received | GRADING OF OCULAR LESIONS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Response after | ||||||||||||||||||
1 hr | 24 hrs | 48 hrs | 72 hrs | |||||||||||||||
Cornea | Iris | Conjunctiva | Chemosis | Cornea | Iris | Conjunctiva | Chemosis | Cornea | Iris | Conjunctiva | Chemosis | Cornea | Iris | Conjunctiva | Chemosis | |||
1 | Wistar rats (Rattus norvegicus) | Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2 | 25 µg | 2 ± 0.6 | 1.1 ± 0.4 | 1.1 ± 0.4 | 1.1 ± 0.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
3 | 50 µg | 2.6 ± 0.8 | 1.3 ± 0.5 | 2.3 ± 0.5 | 2.1 ± 0.4 | 1.3 ± 0.5 | 0 | 1.1 ± 0.4 | 0 | 3.1 ± 0.4 | 0 | 2.1 ± 0.6 | 0 | 3.8 ± 0.4 | 0 | 3.8 ± 0.4 | 2.1 ± 0.4 | |
4 | 75 µg | 2.6 ± 0.5 | 1.5 ± 0.5 | 1.6 ± 0.5 | 1.8 ± 0.4 | 2.6 ± 0.5 | 0 | 2.1 ± 0.4 | 1.1 ± 0.2 | 3.8 ± 0.4 | 0 | 2.1 ± 0.4 | 1 ± 0.0 | 4 ± 0.0 | 0 | 3.6 ± 0.5 | 2 ± 0.0 | |
5 | 100 µg | 3.5 ± 0.5 | 2.1 ± 0.4 | 2.6 ± 0.5 | 3.1 ± 0.4 | 3.8 ± 0.4 | 1.8 ± 0.4 | 3.1 ± 0.4 | 2 ± 0.0 | 4 ± 0.0 | 0 | 2.6 ± 0.5 | 1 ± 0.0 | 3.8 ± 0.4 | 0 | 3.5 ± 0.5 | 2.1 ± 0.6 | |
