Figure 3
From: Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent
8l induces oxidative stress in S. cervi adults. 8l treatment result increased (A) MDA level; (B) generation of Superoxide anion; (C) H2O2 production and (D) total ROS. 8l results depletion of (E) reduced glutathione level; upregulation of (F) Catalase activity; (G) SOD activity and (H) GST. (I) 8l treatment heightens expression of GST, TrxR, Nrf2, Keap1 and HSP60 in treated parasites. All the experiments were performed in triplicate and repeated for at least five times. *p < 0.05 (One Way ANOVA) was considered statistically significant as compared to control.
