Figure 3
From: SERCA is critical to control the Bowditch effect in the heart
The SERCAA617T mutation induces arrhythmia. (a,b) Typical recordings comparing two individuals with regular and irregular heart rate (a,b). Top: wall displacement, middle panel: each line indicates one event ( = one beat), bottom: periods (intervals of time between maximum of two consecutive peaks) are more variable in (b,c) Raw data and average results (inset) of arrhythmicity index. Mutant SERCAA617T animals exhibit significantly increased heart rate variability at basal heart rate and at the maximal frequency of stimulation. (d) Increased proportion of animal mutant for SERCAA617T exhibit incremented ectopic beats at basal rates and at the maximal frequency of stimulation. Arrhythmia: Control: N = 29, 25, 2. SERCAA617T N = 9, 8, 9. SERCAE442K N = 4, 4, 3. Two way ANOVA followed by Tukey’s test for multiple comparisons was used for statistical analysis. *P < 0.05 (between strains only in basal stimulation), #P < 0.05 (between strains at different frequency stimulation), & P < 0.05 (between strains).
