Figure 1
From: A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1
(A) BTBD9 expression as a function of the genotype of the SNP rs3923809 identified in the GWAS (common allele A as the risk allele) in 44 cases of LCL, 26 cases of pons and 28 cases of thalamus. BTBD9 expression was measured using quantitative RT-PCR Taqman method and did not show any significant difference in LCL or brains from RLS patients. (B) MAP2K5 expression as a function of the genotype of the SNP rs3784709 identified in the GWAS (common allele C as the risk allele) in 29 cases of LCL, 30 cases of pons and 25 cases of thalamus. MAP2K5 expression was measured using the quantitative RT-PCR Taqman method and did not show any significant difference in LCL or brains from RLS patients. (C) SKOR1 expression as a function of the genotype of the same SNP rs3784709 identified in the GWAS (C as the risk allele) in 43 cases of LCL, 30 cases of pons and 29 cases of thalamus. SKOR1 expression was measured using the quantitative RT-PCR Taqman and did not reveal any significant difference in LCL or brains from RLS patients.
