Table 3 Antimicrobial prescription according to illness (DDD/1,000 inhabitants/days).
Illness | Class | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Respiratory disease | Cephem | 1.919 (21) | 1.813 (21) | 1.868 (20) | 2.059 (20) | 2.216 (22) | 2.308 (23) | 3.042 (24) | 3.270 (26) | 3.391 (26) | 3.105 (25) | 3.234 (26) | 3.113 (26) | <0.001 |
Macrolide | 0.686 (7) | 0.838 (10) | 0.952 (10) | 1.150 (11) | 1.305 (13) | 1.557 (15) | 1.973 (16) | 2.167 (17) | 2.418 (18) | 2.559 (21) | 2.498 (20) | 2.307 (19) | <0.001 | |
Penicillin | 4.922 (54) | 4.431 (53) | 5.125 (56) | 5.651 (56) | 5.232 (53) | 5.030 (50) | 5.895 (48) | 5.755 (46) | 5.835 (45) | 5.345 (44) | 5.441 (44) | 5.281 (45) | 0.075 | |
Fluoroquinolone | 0.519 (5) | 0.503 (6) | 0.498 (5) | 0.559 (5) | 0.543 (5) | 0.604 (6) | 0.764 (6) | 0.745 (6) | 0.700 (5) | 0.694 (5) | 0.737 (6) | 0.697 (5) | <0.001 | |
Subtotal amount | 9.002 (56) | 8.265 (51) | 9.032 (51) | 9.988 (51) | 9.777 (49) | 9.968 (48) | 12.171 (50) | 12.390 (51) | 12.759 (50) | 12.074 (48) | 12.232 (49) | 11.683 (48) | <0.001 | |
Upper respiratory tract infection | Cephem | 1.012 (20) | 0.928 (21) | 0.934 (20) | 1.028 (20) | 0.855 (21) | 0.935 (23) | 1.229 (24) | 1.269 (26) | 1.289 (26) | 1.045 (26) | 1.029 (26) | 0.963 (26) | 0.264 |
Macrolide | 0.266 (5) | 0.269 (6) | 0.297 (6) | 0.367 (7) | 0.334 (8) | 0.394 (9) | 0.529 (10) | 0.566 (11) | 0.644 (13) | 0.558 (13) | 0.557 (14) | 0.504 (13) | <0.001 | |
Penicillin | 2.879 (58) | 2.520 (58) | 2.839 (62) | 3.106 (62) | 2.438 (60) | 2.316 (57) | 2.776 (56) | 2.603 (54) | 2.562 (53) | 2.128 (53) | 2.054 (52) | 1.951 (53) | 0.005 | |
Fluoroquinolone | 0.243 (4) | 0.226 (5) | 0.208 (4) | 0.225 (4) | 0.189 (4) | 0.198 (4) | 0.241 (4) | 0.225 (4) | 0.193 (4) | 0.160 (4) | 0.156 (4) | 0.132 (3) | 0.003 | |
Subtotal amount | 4.900 (30) | 4.279 (26) | 4.552 (25) | 4.982 (25) | 4.000 (20) | 4.012 (19) | 4.949 (20) | 4.817 (20) | 4.824 (19) | 3.999 (16) | 3.886 (15) | 3.625 (14) | 0.109 | |
Genito-urinary disease | Cephem | 0.173 (12) | 0.233 (14) | 0.258 (16) | 0.297 (18) | 0.330 (19) | 0.388 (19) | 0.460 (19) | 0.453 (19) | 0.471 (20) | 0.479 (20) | 0.484 (20) | 0.488 (21) | <0.001 |
Macrolide | 0.024 (1) | 0.029 (1) | 0.028 (1) | 0.034 (2) | 0.048 (2) | 0.052 (2) | 0.061 (2) | 0.061 (2) | 0.067 (2) | 0.070 (2) | 0.077 (3) | 0.074 (3) | <0.001 | |
Penicillin | 0.382 (27) | 0.381 (23) | 0.361 (22) | 0.354 (21) | 0.327 (18) | 0.255 (12) | 0.229 (9) | 0.203 (8) | 0.192 (8) | 0.185 (7) | 0.172 (7) | 0.167 (7) | <0.001 | |
Fluoroquinolone | 0.352 (25) | 0.482 (30) | 0.502 (31) | 0.532 (32) | 0.566 (32) | 0.668 (34) | 0.829 (34) | 0.814 (35) | 0.829 (35) | 0.847 (35) | 0.843 (35) | 0.796 (34) | <0.001 | |
Subtotal amount | 1.381 (8) | 1.593 (9) | 1.589 (8) | 1.646 (8) | 1.724 (8) | 1.979 (9) | 2.372 (9) | 2.322 (9) | 2.341 (9) | 2.383 (9) | 2.382 (9) | 2.302 (9) | <0.001 | |
Urinary tract infection | Cephem | 0.057 (10) | 0.073 (11) | 0.078 (12) | 0.088 (13) | 0.096 (13) | 0.114 (14) | 0.138 (14) | 0.140 (15) | 0.152 (16) | 0.157 (16) | 0.170 (17) | 0.182 (19) | <0.001 |
Macrolide | 0.015 (2) | 0.015 (2) | 0.015 (2) | 0.018 (2) | 0.021 (3) | 0.022 (2) | 0.023 (2) | 0.022 (2) | 0.025 (2) | 0.023 (2) | 0.026 (2) | 0.025 (2) | <0.001 | |
Penicillin | 0.080 (14) | 0.093 (14) | 0.089 (13) | 0.086 (12) | 0.084 (12) | 0.076 (9) | 0.072 (7) | 0.064 (7) | 0.065 (6) | 0.065 (6) | 0.063 (6) | 0.061 (6) | <0.001 | |
Fluoroquinolone | 0.177 (32) | 0.245 (37) | 0.248 (38) | 0.272 (40) | 0.282 (40) | 0.333 (41) | 0.404 (43) | 0.388 (43) | 0.411 (43) | 0.426 (45) | 0.434 (44) | 0.412 (43) | <0.001 | |
Subtotal amount | 0.542 (3) | 0.656 (4) | 0.641 (3) | 0.671 (3) | 0.700 (3) | 0.801 (3) | 0.923 (3) | 0.892 (3) | 0.938 (3) | 0.940 (3) | 0.968 (3) | 0.942 (3) | <0.001 | |
Total amount | 15.943 | 16.142 | 17.656 | 19.272 | 19.753 | 20.482 | 23.958 | 23.836 | 25.107 | 24.732 | 24.899 | 24.219 | <0.001 | |
