Figure 6
From: Repurposing Thioridazine (TDZ) as an anti-inflammatory agent
TDZ treatment decreases NF-kB mediated transcriptional activation of pro-inflammatory cytokine expression in the lung tissue. (A–D) qPCR quantification of NF-kB dependent molecular signatures NOS2 (A), TNFα (B), IL1β (C), and IL6 (D) in mice lung treated with LPS or LPS + TDZ for 24 h. TDZ treatment significantly decreased the induction of NF-kB dependent pro-inflammatory molecular markers. Values are mean ± standard error and treatment groups were normalized to GAPDH. ***P < 0.05, §§<0.005.
