Figure 8 | Scientific Reports

Figure 8

From: Glycosylation Significantly Inhibits the Aggregation of Human Prion Protein and Decreases Its Cytotoxicity

Figure 8

N-linked glycosylation deficiency enhances PrP toxicity in RK13 cells induced by the toxic prion peptide PrP 106–126. RK13 cells stably expressing wild-type PrP (a), V180I (b), N197D (c), or the double mutant N181D/N197D (d) were cultured for 3 days and incubated with 60 μM PrP 106–126 for 2 days. The percentage of apoptotic cells was determined by flow cytometry as described in the legend of Fig. 7.

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